Prediction and analysis of gene regulatory networks in prokaryotic genomes
Title | Prediction and analysis of gene regulatory networks in prokaryotic genomes |
Publication Type | Book Chapter |
Year of Publication | 2011 |
Authors | Münch, R, Klein, J, Jahn, D |
Book Title | Systems and Computational Biology - Molecular and Cellular Experimental Systems |
Chapter | 8 |
Pagination | 149-162 |
Publisher | InTech |
City | Rijeka, Croatia |
ISBN Number | 978-953-307-280-7 |
Abstract | The availability of over 1500 completely sequenced and annotated prokaryotic genomes offers a variety of comparative and predictive approaches on genome-scale. The results of such analyses strongly rely on the quality of the employed data and the computational strategy of their interpretation. Today, comparative genomics allows for the quick and accurate assignment of genes and often their corresponding functions. The resulting list of classified genes provides information about the overall genomic arrangement, of metabolic capabilities, general and unique cellular functions, however, almost nothing about the underlying complex regulatory networks. Transcriptional regulation of gene expression is a central part of these networks in all organisms. It determines the actual RNA, protein and as a consequence metabolite composition of a cell. Moreover, it allows cells to adapt these parameters in response to changing environmental conditions. An integral part of transcriptional regulation |
URL | http://www.intechopen.com/download/pdf/pdfs_id/20314 |
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