Cannibalism Stress Response in Bacillus subtilis.

TitleCannibalism Stress Response in Bacillus subtilis.
Publication TypeJournal Article
Year of Publication2015
AuthorsHöfler, C, Heckmann, J, Fritsch, A, Popp, P, Gebhard, S, Fritz, G, Mascher, T
JournalMicrobiology
Date Published2015 Sep 11
ISSN1465-2080
Abstract

When faced with carbon source limitation, the Gram-positive soil organism Bacillus subtilis initiates a survival strategy called sporulation, which leads to the formation of highly resistant endospores that allow B. subtilis to survive even long periods of starvation. In order to avoid commitment to this energy-demanding and irreversible process, B. subtilis employs another strategy called cannibalism to delay sporulation as long as possible. Cannibalism involves the production and secretion of two cannibalism toxins, the sporulation delaying protein, SDP, and the sporulation killing factor, SKF, which are able to lyse sensitive siblings. The lysed cells are thought to then provide nutrients for the cannibals to slow down or even prevent them from entering sporulation. In this study, we uncovered the role of the cell envelope stress response (CESR), especially the Bce-like antimicrobial peptide detoxification modules, in cannibalism stress response during stationary phase. SDP and SKF specifically induce Bce-like systems and some ECF σ factors in stationary phase cultures, but only the latter provide some degree of protection. A full Bce response is only triggered by mature toxins, but not by toxin precursors. Our study provides insights into the close relationship between stationary phase survival and the CESR of B. subtilis.

DOI10.1099/mic.0.000176
Alternate JournalMicrobiology (Reading, Engl.)