Impact of spontaneous prophage induction on the fitness of bacterial populations and host-microbe interactions.

TitleImpact of spontaneous prophage induction on the fitness of bacterial populations and host-microbe interactions.
Publication TypeJournal Article
Year of Publication2015
AuthorsNanda, AM, Thormann, KM, Frunzke, J
JournalJ Bacteriol
Volume197
Issue3
Pagination410-9
Date Published2015 Feb
ISSN1098-5530
KeywordsAdaptation, Biological, Bacteria, Host-Pathogen Interactions, Prophages, Virus Activation
Abstract

Bacteriophages and genetic elements, such as prophage-like elements, pathogenicity islands, and phage morons, make up a considerable amount of bacterial genomes. Their transfer and subsequent activity within the host's genetic circuitry have had a significant impact on bacterial evolution. In this review, we consider what underlying mechanisms might cause the spontaneous activity of lysogenic phages in single bacterial cells and how the spontaneous induction of prophages can lead to competitive advantages for and influence the lifestyle of bacterial populations or the virulence of pathogenic strains.

DOI10.1128/JB.02230-14
Alternate JournalJ. Bacteriol.