'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution.

Title'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution.
Publication TypeJournal Article
Year of Publication2013
AuthorsStecher, B, Maier, L, Hardt, W-D
JournalNat Rev Microbiol
Volume11
Issue4
Pagination277-84
Date Published2013 Apr
ISSN1740-1534
KeywordsAnimals, Anti-Bacterial Agents, Bacteria, Biological Evolution, Diet, Drug Resistance, Microbial, Gastrointestinal Tract, Gene Transfer, Horizontal, Immunity, Intestines, Mammals, Metagenome, Virulence Factors
Abstract

Hundreds of bacterial species make up the mammalian intestinal microbiota. Following perturbations by antibiotics, diet, immune deficiency or infection, this ecosystem can shift to a state of dysbiosis. This can involve overgrowth (blooming) of otherwise under-represented or potentially harmful bacteria (for example, pathobionts). Here, we present evidence suggesting that dysbiosis fuels horizontal gene transfer between members of this ecosystem, facilitating the transfer of virulence and antibiotic resistance genes and thereby promoting pathogen evolution.

DOI10.1038/nrmicro2989
Alternate JournalNat. Rev. Microbiol.