The Aldous-Shields model revisited with application to cellular ageing

TitleThe Aldous-Shields model revisited with application to cellular ageing
Publication TypeJournal Article
Year of Publication2010
AuthorsBest, K, Pfaffelhuber, P
JournalElec. Comm. Probab.
Volume15
Start Page475
Pagination14
Abstract

In Aldous and Shields (1988), a model for a rooted, growing random binary tree was presented. For some c>0, an external vertex splits at rate c^(-i) (and becomes internal) if its distance from the root (depth) is i. For c>1, we reanalyse the tree profile, i.e. the numbers of external vertices in depth i=1,2,.... Our main result are concrete formulas for the expectation and covariance-structure of the profile. In addition, we present the application of the model to cellular ageing. Here, we assume that nodes in depth h+1 are senescent, i.e. do not split. We obtain a limit result for the proportion of non-senescent vertices for large h.