Streptomycin-induced expression in Bacillus subtilis of YtnP, a lactonase-homologous protein that inhibits development and streptomycin production in Streptomyces griseus.

TitleStreptomycin-induced expression in Bacillus subtilis of YtnP, a lactonase-homologous protein that inhibits development and streptomycin production in Streptomyces griseus.
Publication TypeJournal Article
Year of Publication2012
AuthorsSchneider, J, Yepes, A, Garcia-Betancur, JC, Westedt, I, Mielich, B, López, D
JournalAppl Environ Microbiol
Volume78
Issue2
Pagination599-603
Date Published2012 Jan
ISSN1098-5336
KeywordsAmino Acid Sequence, Bacillus subtilis, Carboxylic Ester Hydrolases, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Enzymologic, Molecular Sequence Data, Streptomyces griseus, Streptomycin
Abstract

Bacillus subtilis induces expression of the gene ytnP in the presence of the antimicrobial streptomycin, produced by the Gram-positive bacterium Streptomyces griseus. ytnP encodes a lactonase-homologous protein that is able to inhibit the signaling pathway required for the streptomycin production and development of aerial mycelium in S. griseus.

DOI10.1128/AEM.06992-11
Alternate JournalAppl. Environ. Microbiol.