Publications

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2016
Sachs CC, Grünberger A, Helfrich S, Probst C, Wiechert W, Kohlheyer D, Nöh K. Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments. PLoS One. 2016;11(9):e0163453.
2015
Helfrich S, Pfeifer E, Krämer C, Sachs CC, Wiechert W, Kohlheyer D, Nöh K, Frunzke J. Live cell imaging of SOS and prophage dynamics in isogenic bacterial populations. Mol Microbiol. 2015.
Grünberger A, Probst C, Helfrich S, Nanda A, Stute B, Wiechert W, von Lieres E, Nöh K, Frunzke J, Kohlheyer D. Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform. Cytometry A. 2015.
Helfrich S, Azzouzi CE, Probst C, Seiffarth J, Grünberger A, Wiechert W, Kohlheyer D, Nöh K. Vizardous: interactive analysis of microbial populations with single cell resolution. Bioinformatics. 2015.
2014
Unthan S, Grünberger A, van Ooyen J, Gätgens J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D, Noack S. Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium. Biotechnol Bioeng. 2014;111(2):359-71.
Grünberger A, Wiechert W, Kohlheyer D. Single-cell microfluidics: opportunity for bioprocess development. Curr Opin Biotechnol. 2014;29C:15-23.
2013
Probst C, Grünberger A, Wiechert W, Kohlheyer D. Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes. J Microbiol Methods. 2013;95(3):470-6.
Probst C, Grünberger A, Wiechert W, Kohlheyer D. Polydimethylsiloxane (PDMS) Sub-Micron Traps for Single-Cell Analysis of Bacteria. Micromachines. 2013;4(4):357-369.
2012
Grünberger A, van Ooyen J, Paczia N, Rohe P, Schiendzielorz G, Eggeling L, Wiechert W, Kohlheyer D, Noack S. Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments. Biotechnol Bioeng. 2012.
Grünberger A, Paczia N, Probst C, Schendzielorz G, Eggeling L, Noack S, Wiechert W, Kohlheyer D. A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab Chip. 2012;12(11):2060-8.
2011
Hou B-H, Takanaga H, Grossmann G, Chen L-Q, Qu X-Q, Jones AM, Lalonde S, Schweissgut O, Wiechert W, Frommer WB. Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells. Nat Protoc. 2011;6(11):1818-33.
2006
Nöh K, Wahl A, Wiechert W. Computational tools for isotopically instationary 13C labeling experiments under metabolic steady state conditions. Metab Eng. 2006;8(6):554-77.
1996
Kinder M, Wiechert W. Stochastic simulation of biotechnical processes. Mathematics and Computers in Simulation 42 (2-3):17 [Internet]. 1996;42(2-3): 171–178. Available from: http://dx.doi.org/10.1016/0378-4754(95)00130-1