Publications

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Journal Article
Helfrich S, Azzouzi CE, Probst C, Seiffarth J, Grünberger A, Wiechert W, Kohlheyer D, Nöh K. Vizardous: interactive analysis of microbial populations with single cell resolution. Bioinformatics. 2015.
Kinder M, Wiechert W. Stochastic simulation of biotechnical processes. Mathematics and Computers in Simulation 42 (2-3):17 [Internet]. 1996;42(2-3): 171–178. Available from: http://dx.doi.org/10.1016/0378-4754(95)00130-1
Grünberger A, Probst C, Helfrich S, Nanda A, Stute B, Wiechert W, von Lieres E, Nöh K, Frunzke J, Kohlheyer D. Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform. Cytometry A. 2015.
Grünberger A, Wiechert W, Kohlheyer D. Single-cell microfluidics: opportunity for bioprocess development. Curr Opin Biotechnol. 2014;29C:15-23.
Probst C, Grünberger A, Wiechert W, Kohlheyer D. Polydimethylsiloxane (PDMS) Sub-Micron Traps for Single-Cell Analysis of Bacteria. Micromachines. 2013;4(4):357-369.
Hou B-H, Takanaga H, Grossmann G, Chen L-Q, Qu X-Q, Jones AM, Lalonde S, Schweissgut O, Wiechert W, Frommer WB. Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells. Nat Protoc. 2011;6(11):1818-33.
Probst C, Grünberger A, Wiechert W, Kohlheyer D. Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes. J Microbiol Methods. 2013;95(3):470-6.
Helfrich S, Pfeifer E, Krämer C, Sachs CC, Wiechert W, Kohlheyer D, Nöh K, Frunzke J. Live cell imaging of SOS and prophage dynamics in isogenic bacterial populations. Mol Microbiol. 2015.
Sachs CC, Grünberger A, Helfrich S, Probst C, Wiechert W, Kohlheyer D, Nöh K. Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments. PLoS One. 2016;11(9):e0163453.
Grünberger A, Paczia N, Probst C, Schendzielorz G, Eggeling L, Noack S, Wiechert W, Kohlheyer D. A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab Chip. 2012;12(11):2060-8.
Nöh K, Wahl A, Wiechert W. Computational tools for isotopically instationary 13C labeling experiments under metabolic steady state conditions. Metab Eng. 2006;8(6):554-77.
Unthan S, Grünberger A, van Ooyen J, Gätgens J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D, Noack S. Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium. Biotechnol Bioeng. 2014;111(2):359-71.
Grünberger A, van Ooyen J, Paczia N, Rohe P, Schiendzielorz G, Eggeling L, Wiechert W, Kohlheyer D, Noack S. Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments. Biotechnol Bioeng. 2012.